Mechanistic studies of -arylsulfotransferase IV
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چکیده
منابع مشابه
Mechanistic studies of -arylsulfotransferase IV
Sulfotransferases are an important class of enzymes that catalyze the transfer of a sulfuryl group to a hydroxyl or amine moiety on various molecules including small-molecule drugs, steroids, hormones, carbohydrates, and proteins. They have been implicated in a number of disease states but remain poorly understood, complicating the design of specific, small-molecule inhibitors. A linear free-en...
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Background: Allylsilanes which possess a siloxy group in the α position have been shown to rearrange under Lewis acid catalysis to afford vinyl silanes (eq 1). To understand this reaction completely, we need to know the exact mechanism by which it occurs. Currently two mechanisms may be postulated for the rearrangement; one involves a concerted pericyclic process and the second involves a stepw...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2003
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0337638100